1 Prilosec OTC pill each morning lets you block heartburn for 24 hrs. Heartburn occurs when stomach acid refluxes into the esophagus, causing discomfort. Prilosec OTC's omeprazole allows the active ingredient, omeprazole, to pass through stomach acid to prevent excess acid production providing lasting heartburn relief. Other heartburn relief treatments only neutralize acid after it's produced, offering shorter relief lasting less than 24 hrs. Prilosec OTC heartburn medicine stands out; unlike traditional antacids omeprazole blocks acid production providing powerful heartburn relief that antacids can't match. Take control of your comfort with Prilosec OTC omeprazole. Experience the difference that daily use of omeprazole heartburn medicine can make in your life.